慢性充血性心力衰竭患者血清 CA125水平与临床心功能的相关性研究

摘要

Objective To study the correlation of serum CA125 level and clinical cardiac function grading in patients with chronic congestive heart failure. Methods A total of 1 10 patients with chronic congestive heart failure cared at our hospital from May 2013 to May 2014 were enrolled in this study as the research ob-jects,proven by color Doppler echocardiography and laboratory test.According to New York Heart Associa-tion (NYHA)Standard,the cardiac function were divided into gradesⅡ,Ⅲ and Ⅳ,and 30 healthy individuals in check-up treated in the same period were chosen as controls.The electrochemical luminescence technology was used to determine CA125 level in subjects of four groups,comparison and analysis of the relationship be-tween different heart function and serum CA125 level were done. Results Patients with chronic congestive heart failure had significantly higher serum CA125 levels than the normal control group;in addition,cardiac function grade Ⅳgroup had significantly higher serum CA125 levels than the cardiac function grade Ⅲ group, and cardiac function grade Ⅲ group had significantly higher serum CA125 level than cardiac function gradeⅡgroup,group-paired comparison yielded statistical significant difference(P < 0.05 ). Conclusion Serum CA125 level was closely related to the severity of heart failure in patients with chronic congestive heart failure, with the heart failure worsened and the serum levels of CA125 increased,serum CA125 can be clinically used as one of indicators of cardiac damage in patients with heart failure.%目的：探讨慢性充血性心力衰竭患者血清 CA125水平与临床心功能分级的关系性。方法选择我院2013年5月~2014年5月期间收治的慢性充血性心力衰竭患者共110例作为研究对象，采用彩色多普勒超声心动图及实验室检查确诊，并按纽约心脏协会(NYHA)标准将心功能分为Ⅱ级、Ⅲ级、Ⅳ级，并以同期收治的健康体检者30例作为对照。采用电化学发光技术测定四组受检者的 CA125水平，对比分析不同等级心功能与血清 CA125水平的关系。结果慢性充血性心力衰竭患者的血清 CA125水平显著高于正常对照组；另外，心功能Ⅳ级组的血清 CA125水平显著高于心功能Ⅲ级组，而心功能Ⅲ级组的血清 CA125水平又显著高于心功能Ⅱ级组，两组间差异比较均具有统计学意义(P <0.05)。结论慢性充血性心力衰竭患者血清 CA125水平与其心力衰竭的严重程度密切有关，血清 CA125水平随着心力衰竭的加剧而增高，临床可作为反映心力衰竭患者心功能损害程度的指标之一。