戊型肝炎临床特征研究

摘要

目的：研究戊型肝炎患者肝炎临床特征、病程经过及可能反映患者预后的预测指标。方法91例戊型肝炎患者，按年龄分为青壮年组（n＝22）、中年组（n＝48）、老年组（n＝21），比较各组间肝功能水平和住院时间的差别。根据肝功能各指标异常程度分组，比较各组间患者住院时间的差异，同时分析肝功能指标与住院时间的关系。结果老年组血胆红素水平高于青壮年组和中年组（P＜0．05），血白蛋白水平低于青壮年、中年组（P＜0．05）。老年组患者住院时间明显长于青壮年组和中年组（P＜0．05）。血胆红素水平显著升高及血白蛋白水平降低的患者住院时间较长（ P＜0．05）。结论戊型肝炎发病年龄高峰在46～65岁。戊型肝炎住院患者胆红素升高显著，胆红素水平是反映患者预后的较重要指标。戊型肝炎患者的年龄、血白蛋白水平是与肝炎轻重程度以及预后相关的因素。%Objective To study the clinical features and clinical course of hepatitis E and the factors which may predict the prognosis of the disease .Methods According to age, 91 cases of hepatitis E patients were divided into the young group (n=22), middle age group (n=48) and elderly group (n=21).The liver functions and the time of hos-pitalization of these patients were compared .The relationship between liver functions and the time of hospitalization were analyzed.Results The levels of total bilirubin (TBIL) in the elderly group were significantly higher than in the middle age group and young group (P<0.05).The levels of albumin (ALB) in the elderly group were lower than in the middle age group and young group (P<0.05).The time of hospital stay was significantly longer in the elderly group than in the middle age group and young group ( P<0.05) .The time of hospital stay was longer in patients with higher levels of TBIL or lower levels of ALB (P<0.05).Conclusions The peak age of hepatitis E onset is 46 to 55 years old, so most of the patients with hepatitis E are elderly .The patients with hepatitis E are prone to suffer from hyperbilirubinemia .TBIL is an important index to predict prognosis of patients with hepatitis E .The age of patients and the levels of ALB are important factors influencing the recovery of the patients with hepatitis E .