香菇多糖对晚期胃癌患者围化疗期细胞免疫功能的影响

摘要

目的：观察香菇多糖对晚期胃癌患者围化疗期细胞免疫功能的影响。方法62例经病理学或细胞学证实的晚期胃癌患者随机分为A、B两组：A组（35例）采用香菇多糖加DCF方案（多西他赛＋顺铂＋5-氟尿嘧啶）化疗，B组（27例）采用单纯DCF方案化疗。疗程结束后测定2组T细胞亚群、自然杀伤细胞（ NK细胞）活性变化。结果 A组患者T细胞中CD3、CD4、CD4/CD8及NK显著高于治疗前，CD8明显低于治疗前（P＜0．05）；B组变化趋势则与之相反（P＜0．05）；治疗后，A组T细胞中CD3、CD4、CD4/CD8及NK显著高于B组（P＜0．05）。结论香菇多糖可显著提高晚期胃癌患者围化疗期的细胞免疫功能。%Objective To investigate the effects of lentinan on the cellular immune function of patients with ad-vanced gastric cancer during perichemotherapy .Methods 62 patients diagnosed with advanced gastric cancer by patho-logical and cytological tests were randomized into groups A and B:group A ( 35 cases ) were treated with lentinan com-bined with DCF regimen ( docetaxel , cisplatin and 5-fluorouracil ) and group B ( 27 cases ) received DCF regimen a-lone.After chemotherapy, the activities of T lymphocyte subgroups and natural kill (NK) cells were measured.Results In group A, the levels of CD3, CD4, CD4 /CD8 and NK cells were obviously elevated after treatment .The amounts of CD8 was remarkably reduced when compared with the pre -treatment level (P<0.05).An opposite trend was observed in the control group (P<0.05).The levels of CD3, CD4, CD4 /CD8 and NK cells were significantly higher in group A than in group B (P<0.05).Conclusion Lentinan can remarkably enhance the cellular immune function of patients with advanced gastric cancer during perichemotherapy .