首次入院精神分裂症患者血糖变化及其相关因素分析

摘要

Objective To explore blood sugar levels changes in the first time for hospitalized schizophrenia patients with different gender,age,clinical types,medication,and so forth.Methods To compare the fasting glucose at the end of 4 w,before and after treatment in 422 cases of patients with first-episode schizophrenia,and analyze the changes in different gender,age,clinical subtypes,medication.Results After treatment of 4 w antipsychotic drugs in 422 patients mean blood glucose was significantly lower than before treatment,the difference was statistically significant.Blood sugar levels in different age groups taken made pp with olanzapine was statistically difference Influence on blood sugar levels of below or over 20 years old age group with different types of drugs were obvious difference.Before and after different types of drugs treatment in male and female patients with no statistically significant difference were ob-served in the changes of blood sugar levels.The blood glucose levels in mixed schizophrenia patients after taking made pp and risperidone treatment was significantly lower than before.The tendency of blood glu-cose levels reduced to 0.30 mmol/L in mixed patients after taking risperidone,whereas increased to 0.09 mmol/L in paranoid patients after taking risperidone,the difference was statistically significant.The ris-peridone effects on blood sugar levels ware statistically significant.in different clinical subtypes.Conclusion It is necessary to combat psychiatric medications in patients with glucose metabolism index monitoring, avoiding or reducing the drug adverse reactions,improving patient′s quality of life.%目的：探讨首次入院精神分裂症患者服用抗精神病药物后血糖水平的变化及其相关影响因素。方法比较422例首发精神分裂症患者用药前和用药后第4 w末的空腹血糖，并分析性别、年龄、临床亚型、服药情况对首发精神分裂症患者血糖的影响。结果（1）422例患者抗精神病药物治疗4 w后血糖均值显著低于治疗前，差异有统计学意义。（2）不同年龄组服用阿立哌唑和奥氮平的患者的血糖值变化差异有统计学意义，＜20岁和20～岁年龄组不同类型药物对血糖水平的影响有明显差异。（3）男、女性患者服用不同类型药物治疗前后血糖值变化差异均无统计学意义。（4）混合型精神分裂症患者服用阿立哌唑和利培酮治疗后血糖值均较治疗前有明显降低。混合型患者服用利培酮后血糖降低了0．30 mmol/L，偏执型患者服用利培酮后血糖升高了0．09 mmol/L，差异有统计学意义。（5）利培酮在不同临床亚型中对血糖水平的影响差异有统计学意义。结论有必要对抗精神病药物治疗患者的糖代谢指标进行监测，避免或减轻药物引起的不良反应，提高病人的生活质量。