SAA遗传多态性与冠心病临床预后的关联研究

摘要

目的 探讨血清淀粉样蛋白A(SAA)基因多态性和冠心病预后的关系.方法 采用队列研究的方法,选择经皮冠状动脉内介入治疗(PCI)术后冠心病患者1 068例,其基因分型采用限制性片段长度多态性(RFLP)技术,随访时间定为PCI术后1 a,随访终点为支架内血栓形成、非致死性心肌梗死、总死亡以及出血事件的发生率.结果 研究结果发现,SAA基因多态性和冠心病PCI术后1 a心血管不良事件的发生无相关性.结论 PCI术后患者SAA基因多态性和临床冠心病预后无关联性.%Objective To analyze the relationship between SAA genetic polymorphisms and the prognosis of coronary artery disease (CAD) after PCI.Methods A cohort study was designed to observe the relationship between SAA genetic polymorphisms and prognosis of 1 068 patients with CAD after PCI.RFLP method was used to detect the genotypes.Total of 1 068 patients were fellowed-up for one year,and the outcomes such as stent thrombosis,nonfatal myocardial infarction,total mortality and bleeding events were recorded.Results There was noanyassociation of SAA genetic polymorphisms and adverse prognosis of CAD after PCI.Conclusion The present study suggested thatthere was no relationship between SAA genetic polymorphisms and clinical outcomes of CAD after PCI.