口腔鳞状细胞癌淋巴结转移分子标记物的研究进展

摘要

口腔鳞状细胞癌( oral squamous cell carcinoma,OSCC)是常见的口腔颌面部恶性肿瘤,具有早期局部侵袭和淋巴结转移的特点. 淋巴结转移是影响预后的重要因素. 肿瘤淋巴结转移机制是一个多因素相互协同、相互调控的过程,探索特异性高的淋巴结转移分子标记物对于了解肿瘤的进展具有重要的意义,也是目前转化医学的研究热点,本文就口腔鳞癌淋巴结转移分子标记物研究进展做一综述.%Oral squamous cell carcinoma ( OSCC ) is an oral and maxillofacial malignant tumor, which is characterized by the early local invasion and lymph node metastasis. The lymph node metastasis is one of the most serious prognosis impact factors and the metastasis of cancer is a process controlled by multiple factors. The exploration of the highly specified markers of the lymph node metastasis will improve the understanding of this cancer, which beyond any questions is a hotspot of translational medicine with vital significance. This paper will do the literature review on this research area to show the progress of molecular markers used in the study of lymph node metastasis of oral squamous carcinoma.