首页> 中文期刊>同济大学学报(医学版) >三种金属烤瓷冠修复后龈沟液中MMP-2水平检测

三种金属烤瓷冠修复后龈沟液中MMP-2水平检测

     

摘要

目的 研究镍铬合金、钴铬合金、金合金三组金属烤瓷冠修复前后,龈沟液(gingival crevicular fluid,GCF)中基质金属蛋白酶-2(matrix metalloproteinase,MMP-2)水平变化,提示三种合金烤瓷冠在不同时期对牙周组织的刺激程度.方法 临床随机选择三种金属烤瓷冠修复患者共45例,每组各15例,测定在修复前、修复后1个月、3个月、6个月GCF量并采用双抗体夹心酶联免疫吸附法(ABC-ELISA)检测同期GCF中MMP-2水平.结果 镍铬合金烤瓷冠GCF量、MMP-2水平在不同检测周期差异有显著性(P<0.01),钴铬合金、金合金烤瓷冠修复后MMP-2水平在不同检测周期差异无显著性(P>0.05).结论 MMP-2可作为对不同金属烤瓷冠内冠材料刺激牙周组织的评价指标,临床应采用生物相容性好的合金作为内冠材料.%Objective To measure MMP-2 concentrations in gingival crevicular fluid ( GCF) of porcelain teeth coated with Ni-Cr, Co-Cr or gold alloy at different time period, and to demonstrate the degree of stimulation by these alloy on gingivae. Methods Sandwich enzyme-linked immunosorbent assay(ELISA) was used to determine the concentration and total amount of MMP-2 in gingival crevicular fluids in 45 randomly selected cases of porcelain teeth coated with Ni-Cr, Co-Cr or gold alloy, with 15 cases in each group. The assay was performed before and at 1, 3, 6 months after treatment. Results There was significant difference in the total amounts of MMP-2 and GCF volume for the Ni-Cr alloy coated porcelain teeth in different time period(P<0.01). However, there was no significant difference in MMP-2 concentrations between Co-Cr and gold alloy coated porcelain teeth at different time periods (P > 0. 05 ). Conclusion MMP-2 is a useful assessment criterion for the evaluation of degree of stimulation on gingivae by different alloy coating materials in porcelain teeth.rnThe bio-compatibility of alloy coating for porcelain teeth should be carefully considered for the clinicalrnapplication.

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