骨髓脂肪在骨质疏松骨质量研究中的进展

摘要

随着全球人口老龄化,骨质疏松及其脆性骨折的发病率、致残率将持续攀高.因此,如何在骨量明显下降前就找到一个既变化出现较早,又具有一定发现骨量减少/骨质疏松能力的有效方法及对主要部位脆性骨折风险进行预测是目前的热点问题.成骨细胞与脂肪细胞同祖,成骨-成脂分化失稳态是骨质疏松的致病机制之一.因此,研究骨髓脂肪组织在骨质疏松骨质量中的作用就显得相当重要.笔者就骨髓脂肪在骨质疏松中的致病机制及磁共振波谱在骨质疏松骨质量研究中的进展予以综述.%With the global population aging, the incidence and disability rates of osteoporosis and fragility fracture continue to increase. It is a hot issue to find an effective method for predicting osteoporosis and osteoporotic fracture earlier before the dramatic decline of bone mass appears. Adipocytes and osteoblasts are known to be derived from the same progenitor cells. The lost of steady-state of bone marrow adipocytes is the main pathophysiological basis of the changes of bone microstructure in osteoporosis. Therefore, it is important to research the function of bone marrow adipose tissue in the bone quality for osteoporosis. This article reviews the recent research progress in osteoporosis, particularly in the application of proton MR spectroscopy in evaluation of marrow fat content for bone quality in osteoporosis.