脂肪源性干细胞向心肌细胞诱导分化的研究进展

摘要

Differentiation of Adipose-derived Stem Cells into Cardiomyocytes SHI Yuanyuan1, YANG Xiangqun2. 1 Company 2 of Clinical Medicine; Second Military Medical University, Shanghai 200433, China; 2 Department of Human Anatomy, Research Center of Regenerative Medicine, Second Military Medical University, Shanghai 200433, China. Corresponding author:YANG Xiangqun (E-mail:yangxgq@smmu.edu.cn).[Summary] The use of stem cells in the treatment of myocardial infarct has been strongly pursued in recent years. Due to their availability, feasibility, plasticity, and their potential to differentiate into cardiomyocytes at specific media, adipose-derived stem cells (ASCs) have become an ideal source of donor cells. A significant effort has gone into elucidating which factors and techniques influence this differentiation. The methods and mechanisms of differentiation of ASCs into cardiomyocytes were reviewed in this paper.%脂肪源性干细胞因具有生物学特性稳定、来源广泛、取材方便、数量充足、易于培养扩增的优点，且在特定的诱导条件下可以分化为心肌细胞，有望成为细胞治疗的理想来源。诱导方法的选择，影响分化因素的研究已成为了细胞治疗领域研究的热点。本文就脂肪源性干细胞向心肌细胞诱导分化的方法和机制的研究进展进行综述。