醋酸乌利司他假多晶型分子热分解机理及动力学

摘要

Ulipristal acetate pseudo-polymorph was prepared by cooling crystallization in ethanol.According to TG data,the thermal decomposition of ulipristal acetate pseudo-polymorph included two processes which were desolvation and molecular thermal decomposition as the temperature increased. Non-isothermal thermogravimetry was applied to study the thermal decomposition mechanism and thermal decomposition kinetics of molecular thermal decomposition of ulipristal acetate pseudo-polymorph. Based on different kinetic functions of corresponding molecular thermal decomposition mechanisms and the experimental data of ulipristal acetate pseudo-polymorph,the decomposition mechanism of molecular thermal decompo-sition process was analyzed and estimated,and the corresponding kinetic equation was also obtained.%通过冷却结晶实验制备醋酸乌利司他以乙醇为溶剂的假多晶型晶体。热重实验结果表明醋酸乌利司他假多晶型在升温过程中包含溶剂脱除与分子热分解2个过程。利用非等温热重法对醋酸乌利司他假多晶型的分子热分解过程机理及其动力学进行研究。基于不同热分解机理所对应的反应动力学机理函数，结合醋酸乌利司他假多晶型非等温热分解实验数据，计算估测醋酸乌利司他假多晶型分子热分解的机理，并计算得到这一过程所对应的热分解动力学方程。