湖北青砖茶对 IBS-D 模型大鼠肠道敏感性的影响

摘要

The effects of Hubei Qingzhuan tea on intestinal sensitivity in IBS-D mouse model were investigated. The results showed, compared with the normal group, the control group had a significant reduction in the pain threshold, and marked increase in the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase. Compared with the control group, both the low and high dose of Qingzhuan tea significantly increased the pain threshold and markedly decreased the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase by a dose dependent manner. It is concluded that Qingzhuan tea could significantly decrease the intestinal sensitivity of IBS-D mice, which might be related to the inhibition of serum PGE2, TNF-alpha and tryptase levels.%研究了湖北青砖茶对腹泻型肠易激综合征（IBS-D）模型大鼠肠道的影响。结果表明，与正常组相比，模型组的痛阈值明显降低，血清中炎症因子前列腺素2（PGE2）、肿瘤坏死因子（TNF-α）、类胰蛋白酶的含量明显增加；与模型组比较，湖北青砖茶低剂量组、高剂量组能够显著升高痛阈值，而血清中炎症因子 PGE2、TNF-α、类胰蛋白酶的含量显著降低，且具有剂量依赖性。由此表明湖北青砖茶可降低 IBS-D 模型大鼠的肠道敏感性，其作用机制可能与血清中 PGE2、TNF-α和类胰蛋白酶含量的降低有关。