[Objectives] To investigate the detection rate of HCVcAg in patients co-infected with HBV and HCV, and then to analyze the influence factors. [Methods] HCVcAg and HCV RNA in sera were detected in 88 patients with chronic hepatitis C and 62 patients who were co-infected with HCV and HBV. At the same time, HBV DNA and HBeAg in sera were detected in 62 patients infected with HCV and HBV. Then we analyzed the correlation between HCVcAg and HBeAg / HBV DNA.[Results] The detection rates of HCVcAg in 88 patients with chronic hepatitis C and 62 patients co-infected with HCV and HBV were 72.7% (64/88) and 38.7% (24/62), respectively (x2 = 17.358 ,P < 0.001). The detection rates of HCV RNA in 88 patients with chronic hepatitis C and 62 patients co-infected with HCV and HBV were 81.8% (72/88) and 53.2% (33/62), respectively (x2 = 20.11, P< 0.001). In 62 patients infected with HCV and HBV, the detection rates of HCVcAg in HBeAg positive patients and HBeAg negative patients were 28.6% (12/42) and 60% (12/20), respectively (x2 = 5.641, P = 0.011). Moreover, the positive rates of HBV DNA in HBeAg positive patients and HBeAg negative patients were 42.9% (18/42) and 80% (16/20), respectively (x2= 15.452, P< 0.001). The detection rates of HCVcAg in HBV DNA positive patients and HBV DNA negative patients were 39.1% (18/46) and 37.5% (6/16), respectively (x2 = 0.013, P= 0.908). Compared with the detection rate of HCVcAg in patients only infected with HCV, the detectionrates of HCVcAg in HBeAg or HBV DNA negative patients infected with HCV and HBV were 60% (12/20) (x2 = 1.266, P = 0.261) and 37.5% (6/16)(x2 = 7.635,P< 0.01), respectively. [Conclusions] The detection rate of HCVcAg in patients infected with HCV and HBV is relatively low. The reason is possibly that HBeAg inhibits duplication of HCV and decreases the expression of HCVcAg.%摘要:[目的]探讨丙型肝炎病毒核心抗原(HCVcAg)在乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)合并感染者血清中的检出状况,并分析其影响因素.[方法]检测88例慢性丙型肝炎和62例HBV/HCV合并感染患者血清HCVcAg和HCVRNA,对后者血清进行HBV DNA、HBeAg检测,分析HCVcAg检出率与HBeAg、HBV DNA定量检测关系.[结果]88例慢性丙型肝炎和62例HBV/HCV合并感染者血清HCVcAg的检出率分别是72.7％ (64/88)和38.7％( 24/62),X2=17.358,P＜0.001,HCV RNA检出率分别是81.8％( 72/88)和53.2％(33/62),X2=20.11,P＜ 0.001；62例HBV/HCV合并感染者血清中,HBeAg阳性和HBeAg阴性感染者HCVcAg检出率分别为28.6％(12/42)和60％ (12/20),X2=5.641,P=0.011,HCV RNA阳性率分别为42.9％(18/42)和80％ (16/20),X2=15.452,P＜0.001；HBV DNA阳性和阴性时HCVeAg检出率分别为39.1％(18/46)和37.5％(6/16),X2=0.013,P=0.908;与单纯HCV感染者血清HCVcAg检出率72.7％(64/88),相比较HBeAg阴性合并感染者为60％ (12/20),X2=1.266,P=0.261,HBV DNA阴性合并感染者37.5％(6/16),X2=7.635,P＜0.01.[结论]HBV/HCV合并感染时HCVeAg检出率较低,可能是由于HBeAg抑制HCV的复制,从而减少HCVcAg的表达所致.
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