Objective To evaluate the biomechanical properties of geneX cements for use in vertebroplasty in a calf osteoporotic vertebral compression fracture model.Methods Thirty vertebral bodies (T9-L4) were harvested from 4 fresh calf spines.The bone mineral density was measured with dual-energy radiographic absorption.Osteoporotic vertebral model was induced in each vertebra using decalcifying chemical agents,and was then compressed to determine their initial strength and stiffness before injecting the cement.Thirty vertebral bodies were divided randomly into geneX? cement group,CSC group,and PMMA group.The fractures were repaired using a transpedicular injection of cements and recompressed to measure posttreament strength and stiffness.Results The normal mean BMD of the calf vertebra was 1.425±0.072 g/cm2,which was reduced significantly to 1.074±0.065 g/cm2 after decalcification.The mean injected volume was similar between geneX? (4.5±0.7 ml),CSC (4.3±0.8 ml) and PMMA (3.8+0.4 ml) groups.The vertebral strength was restored after the treatment to 1198±529 N in geneX? group,1212+430 N in CSC group and 1672±704 N in PMMA group.All the cements produced significantly greater strength than the initial strength {P<0.05).The augmented strength in geneX? and CSC groups were similar (P>0.05),but both were significantly less than that in PMMA group (P<0.05).The stiffness in geneX?,CSC,and PMMA groups was 233+130,242+ 191,and 323±145 N/mm,respectively,showing no significant difference between them (P>0.05).No significant difference was found in the augmented stiffness among the 3 cements (P>0.05).Conclusions geneX? cement is a useful alternative to PMMA in vertebroplasty for osteoporotic vertebral compression fractures,but further study is needed to evaluate its biosorption in vivo.%目的 评估geneX(R)骨水泥用于强化骨质疏松椎体的生物力学性能.方法 对30个新鲜小牛胸腰椎椎体标本(T9-L4)通过注射泵灌注稀盐酸脱钙建立骨质疏松椎体模型.随机分为3组,每组10例.制成压缩性骨折模型后,3组分别实施geneX(R)骨水泥、硫酸钙骨水泥(cSc)、聚甲基丙烯酸甲酯骨水泥(PMMA)椎体成形术,记录骨水泥完本填充时的骨水泥注射量,测试标本的强度和刚度,记录各组的强度和刚度并进行比较.结果 30个小牛胸腰椎体初始骨密度为(1.425±0.072) g/cm2,脱钙后骨密度为(1.074±0.065)g/c m2,脱钙后骨密度明显低于脱钙前骨密度(P＜0 05).geneX(R)组、CSC组、PMMA组注射量分别(4.3±0.8)、(4 2±0.7)和(3.8±0.4) ml,3组之间无显著性差异(P＞0.05).geneX(R)组、CSC组、PMMA组强度分别(1198±529)、(1212±430)和(1672±704)N,geneX(R)组、CSC组显著低于PMMA组强度(P＜0.05),3组均明显高于椎体初始强度(P＜0.05).geneX(R)组、CSC组、PMMA组刚度分别为(233±130)、(242±191)与(323±145)N/mm,3组间无显著性差异(P＞0.05),3组刚度均低于椎体初始刚度,但统计学无明显差异(P＞0.05).结论geneX(R)水泥椎体成形术用于骨质疏松压缩性骨折能满足对椎体填充材料的生物力学要求.
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