阿托伐他汀对血脂正常高血压患者血管脉搏波传导速度及细胞因子的影响

摘要

Objective To explore the influence of atorvastatin on pulse wave velocity( PWV ), serum activin A( CATA ), tumor necrosis factor-ct( TNF-α ), interleukin-6( IL-6 ) and high sensitivity C-reactive protein( hs-CRP ) in hypertension patients with normal blood lip-id. Methods Seventy hypertension patients with normal blood lipid were treated with atorvastatin for 8 weeks. The levels of PWV, ACTA,TNF-α,IL-6 and hs-CRP in serum were observed before and after treatment. Results After treatment,the levels of blood pressure and PWV, ACTA, TNF-α, IL-6, hs-CRP in serum significantly decreased ( P < 0. 01 ). Conclusion Atorvastatin can decrease the PWV, levels of ACTA, TNF-α, IL-6, hs-CRP in serum and inhibit the inflammatory reaction in hypertension patients with normal blood lipid.%目的 观察阿托伐他汀对血脂正常高血压患者脉搏波速度(PWV)、血清激活素A(ACTA)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和高敏C反应蛋白(hs-CRP)的影响.方法 70例血脂正常高血压患者服用阿托伐他汀治疗8周,分别于治疗前、后检测患者PWV、血清ACTA、TNF-α、IL-6和hs-CRP含量.结果 治疗后,患者收缩压、舒张压、PWV、血清ACTA、TNF-α、IL-6和hs-CRP含量均比治疗前显著下降(P＜0.01).结论 阿托伐他汀能够降低高血压患者PWV、血清ACTA、TNF-α、IL-6和hs-CRP水平,抑制炎症反应,缓解动脉硬化,从而有益于血压的控制.