影响2型糖尿病患者抑郁发生的因素分析

摘要

Objective To investigate the related risk factors of depression in type 2 diabetes patients. Methods A total of 110 pa-tients with type 2 diabetes in Air Force General Hospital were included in this cross-sectional study and divided into depression group and non-depression group. The patient health questionnaire-9 assessed depressive symptoms. The clinical characteristics( fatty liver, hypoglycemia, number of complications, body mass index, etc. ) ,examination results( creatinine, triglyceride, cholesterol,etc. ) and demographics( gender, age, education, annual income,etc. ) were obtained and analyzed to screen the risk factors by Logistic regres-sion. Results Prevalence of depression was 33. 6%. The incidence of depression was significantly different in patients with hypogly-cemia,use of insulin and fatty liver. and different income, numbers of complication, sport state(P<0. 05). Logistic regression analy-sis showed that hypoglycemia(OR=2. 769, P=0. 047) and the number of complications(P=0. 030) were risk factors. Conclusion The prevalence of depression in type 2 diabetes patients is high, and hypoglycemia and number of complications may be its risk factors.%目的：探讨影响2型糖尿病(T2DM)患者抑郁发生的相关因素。方法对2014-2015年间在中国人民解放军空军总医院就诊的110例T2DM患者进行横断面调查。采用PHQ-9抑郁自评量表进行评分，按抑郁程度分为不伴抑郁组和伴抑郁组，并用统计学方法(卡方检验、t检验、Logistic回归)分析就诊渠道(门诊或住院)、性别、年龄、收入状况、运动状况、降糖方案、有无低血糖反应、糖尿病家族史、脂肪肝、并发症数目、体质量指数、糖化血红蛋白等因素对抑郁状况的影响。结果110例T2DM患者中伴抑郁者37例(33.6%)。卡方检验显示不同就诊渠道、收入、并发症数目、运动状况以及有无低血糖反应、有无使用胰岛素、有无脂肪肝的患者抑郁率差异有统计学意义(P<0.05)。 Logistic回归分析显示，有无低血糖反应及并发症数目是抑郁的危险因素。结论有无低血糖反应及并发症数目是影响2型糖尿病患者抑郁发生的危险因素。