RELATIONSHIP AMONG MYOCARDIAL INFARCTION,INSERTION/DELETION POLYMORPHISM OF FVII GENE PROMOTER REGION AND FVII ACTIVITY

摘要

Objective To explore the relationship among myocardial infarction (MI), promoter region polymorphism of FVII gene and FVII activity in a Chinese population. Methods Denaturing gradient gel electrophoresis technique was used to study promoter region polymorphism of FVII gene ,and plasma FVII activity (FVIIC)was examined by one stage cloning assay in 74 cases with MI as well as 123 normal controls. Results An insertion/deletion polymorphism of l0bp was found in the promoter region. Plasma FVII activity was significantly higher in the myocardial infarction ( P ＜0. 05 ). Conclusion Elevated FVII activity may be a risk factor for myocardial infarction. There is no correlation found between the insertion/deletion polymorphism of FVII gene promoter region and myocardial infarction in a Chinese population (74 MI cases and 123 normal controls).