PERINATAL FETAL WELL-BEING MONITORING: A COMPARISON BETWEEN RANDOMIZED URINARY ESTRIOL/CREATININE AND SERUM FREE ESTRIOL DETERMINATION

摘要

Randomized urinary and blood samples were obtained from three hundred and ninety-two cases of late pregnancies simultaneously for comparison of the validity in perinatal fetal monitoring. The results of randomized urinary estriol/creatinine （RUE₃/C） and serum free estriol （SFE₃） tests revealed that Ⅰ. The coefficient of correlation between RUE₃/C and SFE₃ level were close in either normal or high-risk pregnancies （y=0.1477X+14.2368, r=0.4586, n=170; y=0.1724X+8.6698, r=0.5868, n=222, respectively, P0.001）; 2.92%cases of the false positive rate of RUE₃/C were corrected by SFE₃ test. In cases of pregnancy-induced hypertension （PIH） the false positive rate of RUE₃/C were highest in comparison with those in cuses of other high-risk pregnancies （53.6%）; 3. The correct rate of SFE₃ test in prenatal predication of fetal well-being was significantly higher （95.6%） than that of RUE₃/C （87.3%） （X2=17.77, P0.001）. This paper suggests that RUE₃/C can be used as a first line test for perinatal monitoring. When RUE₃/C value is lower than normal, SFE₃ test should be added to ensure the reliability of perinatal diagnosis, especially in PIH cases. Obviously, to use these two tests for perinatal fetal monitoring simultaneously is better than to use any one test alone.