HOXA1O,Meis1在构建子宫内膜容受性分子网络中的作用

摘要

Embryo implantation is one of the key events in mammal reproduction. As a pleiotropic nuclear transcription factor regulated by estrogen and progestogen, HOXA10 mediates multiple steps of embryonic implantation. HOXA10 plays a pleiotropic regulation role in embryonic implantation through regulating downstream genes. Meis-HOXAIO heterodimers may enhance specificity of HOXA10 binding downstream target genes, which is very important in constructing unique molecular network of endometrial receptivity.%胚胎着床是哺乳动物生殖的关键环节之一.HOXA10作为雌、孕激素直接调控的多效性核内转录因子,介导胚胎着床的多个环节.HOXA10对胚胎着床的多效性调控作用是通过对其下游基因的调控介导.转录因子Meis1可能与HOXA10结合形成异源二聚体,通过增强HOXA10与下游靶基因结合的特异性,从而在构建子宫内膜容受性独特的分子网络中发挥重要作用.