Y染色体性别决定区(Sry):性别决定关键开关

摘要

性发育异常在人类遗传性疾病中很常见,因此性别决定在临床和生物学研究中非常重要.Y染色体性别决定区(sex-determining region of Y-chromosome,Sry)即哺乳动物Y染色体上的睾丸决定基因片段,与性别决定密切相关.本文对Sry基因的结构功能和表达调节及其相关的性别决定分子机制进行了综述.%Sex determination is very important in clinical and biological medicine because sex development disorders are the most common genetic diseases in humans. Sex-determining region of Y-chromosome (Sry) is the mammalian Y-chromosomal testis-determining gene. It is bound up with sex determination. In this paper, we consider issues related to Sry structure and function, its expression and regulation, and relevant molecular mechanisms of sex determination.