Toll样受体4及核因子-кBp65在口腔扁平苔藓中的表达及意义

摘要

Objective: To investigate the possible role of Toll like receptor 4 (TLR4) and nuclear factor-kappaBp65 ( NF-κBp65) in oral lichen planus(OLP). Methods: Immunohistochemical technique SP method was used to detect the expression of TLR4 and NF-KBp65 in 35 OLP cases and 10 normal oral mucosa specimens. The correlation and their respective relationship with clinical features of OLP were statistically analyzed. Results: The positive rates of TLR4 and NF-κBp65 were 66% (23/35) and 89% (31/35) in OLP cases, 30% ( 3/10 ) and 40% (4/10 ) in normal controls, respectively ( case vs control, P < 0. 05 ) . There was a positive correlation between the expression of TLR4 and NF- κBp65 in OLP tissues ( P < 0. 05 ) . Expression of NF- κBp65 was significantly higher in the patients with atrophic-erosive form(P <0. 05) . Conclusion: The over expression of TLR4 and NF-KBp65 in OLP may play a role in the pathogenesis of OLP.%目的:探讨Toll样受体4(toll like receptor 4,TLR4)、核因子-kBp65(nuclear factor-kappaB,NF-kBp65)在口腔扁平苔藓(oral lichen planus,OLP)病损形成及发展中的作用.方法:采用SP免疫组化方法检测35例OLP及10例正常口腔黏膜中TLR4、NF-kBp65的表达情况,分析两者的相关性及其与OLP临床病理特征的关系.结果:OLP病损组织中TLR4、NF-kBp65的阳性率分别为66％(23/35)、89％ (31/35),在正常黏膜组分别为30％ (3/10)和40％ (4/10),组间比较P＜0.05.TLR4和NF-kBp65在OLP病损组织中的表达为正相关关系(P＜0.05).NF-kBp65在网纹型OLP中的表达水平明显高于在萎缩-糜烂型OLP中的表达(P＜0.05).结论:TLR4和NF-kBp65在OLP病损形成中有重要意义.