1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

摘要

Objective To investigate countermeasures and effects of clinical pharmacists participating in the treatment for fluconazole-exposure candidemia,and to provide reference for infectious control in the clinic.Methods Clinical pharmacists used their professional knowledge and suggested utilizing micafungin to treat candidemia,when voriconazole was ineffective in a patient with candidemia and fluconazole exposure history.Results The patient′s candida bloodstream infection was finally con-trolled.Clinical pharmacists were highly complimented from the doctors,nurses and patients.Conclusion Micafungin is effec-tive in treatment of candidemia with a recent (＜30 days) fluconazole exposure history.The participation of clinical pharmacists is helpful to develop individual medicinal therapy in clinical treatment and can improve therapeutic effects.%目的 探讨临床药师参与有氟康唑暴露史念珠菌血症患者治疗的对策及效果,为临床有效控制此类感染提供参考.方法 在伏立康唑治疗该病患者效果不佳的情况下,临床药师建议采用米卡芬净抗念珠菌治疗.结果 患者的念珠菌感染得到有效控制.结论 米卡芬净能有效治疗近期(＜30 d)有氟康唑暴露史的念珠菌血行感染.临床药师参与临床治疗实践,协助制订个体化治疗方案,有利于提高临床药物治疗水平.