转化生长因子-β1与表皮生长因子在成人增生性瘢痕中的表达及意义

摘要

Objective:To investigate transforming growth factor-β1 (TGF-β1 )and epidermal growth facto (EGF)in adults hy-pertrophic scars occurred in possible role,to provide basis for clinical prevention.Methods:The expression of TGF-β1 and EGF in adult hypertrophic scar and adult normal skin was quantitatively detected by SP and ELISA methods.Results:TGF-β1 ,EGF in adults hyper-trophic scars showed high expression,both expressed in adult hyperplastic scar levels were positively correlated.Conclusion:TGF-β1 , EGF in adults hypertrophic scars showed high expression,TGF-β1 and EGF expression levels in adult hypertrophic scars were positively correlated,which provide new ideas for clinical prevention and treatment of skin hypertrophic scars.%目的：初步探讨转化生长因子-β1（transforming growth factor-β1，TGF-β1）和表皮生长因子（epidermal growth fac-tor，EGF）在成人增生性瘢痕发生中可能的作用，为临床防治提供一定的依据。方法：通过 SP 法定性和 ELISA 法定量检测TGF-β1和 EGF 在成人增生性瘢痕和成人正常皮肤中的表达情况。结果：TGF-β1、EGF 在成人增生性瘢痕中呈高表达，二者在成人增生性瘢痕中表达水平呈正相关。结论：TGF-β1、EGF 在成人增生性瘢痕中均呈高表达，TGF-β1和 EGF 在成人增生性瘢痕中的表达水平呈正相关，这为研究临床预防、治疗皮肤增生性瘢痕提供新思路。