二甲双胍缓释片治疗非典型抗精神病药致精神分裂症糖脂代谢紊乱的临床研究

摘要

Objective:To investigate the clinical effect of metformin sustained release tablets on the disorder of schizophrenia and glucose metabolism in schizophrenia caused by atypical antipsychotics.Methods:104 patients with schizophrenia were randomly di-vided into treatment group and control group,52 cases in each group.All patients were treated with atypical antipsychotic agents,and the patients in treatment group were combined with metformin hydrochloride sustained release tablets.Before and after treatment reflec-ting glycemic index including bBody mass index (BMI),fasting blood glucose metabolism blood glucose (FBG)and postprandial 2 h blood glucose (2 h PBG)]and blood fat index [total cholesterol,total cholesterol (TC),triglyceride (TG),low density lipoprotein particles lipoprotein (LDL)],and high-density lipoprotein (high density lipoprotein,HDL)were monitored to record the occurrence of adverse reactions.Results:The magnitude of the decrease of BMI,FBG and 2hpbg after treatment in the treatment group were larger than those in control group (P <0.05).The levels of TC,TG and LDL were reduced after treatment in the treatment group,the increase in HDL levels higher than that of control group (P <0.05 );adverse reaction in the treatment group occurred rate (15.38%)only slightly higher than that of the control group (9.62%)(P >0.05 ).Conclusion:The metformin sustained release tablets have good clinical efficacy,safety and safety for the treatment of schizophrenia and schizophrenia with schizophrenia and schizophrenia.%目的：探讨二甲双胍缓释片对非典型抗精神病药致精神分裂症糖脂代谢紊乱的临床疗效。方法：选取104例精神分裂症患者，随机分为治疗组和对照组，每组各52例。所有患者都使用非典型抗精神病药进行治疗，治疗组患者增加使用二甲双胍缓释片。对患者治疗前后反映血糖的指标：体质量指数（BMI）、空腹血糖（FBG）和餐后2 h 血糖（2 h PBG）和血脂的指标：总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）进行监测，记录不良反应发生情况。结果：治疗组患者治疗后 BMI、FBG 和2 h PBG 降低的幅度超过对照组（P ＜0．05）；治疗组患者治疗后 TC、TG 和 LDL 降低的水平与 HDL 升高的水平均超过对照组（P ＜0．05）；治疗组不良反应发生率（15．38％）仅稍高于对照组（9．62％）（P ＞0．05）。结论：二甲双胍缓释片对非典型抗精神病药致精神分裂症糖脂代谢紊乱具有较好的临床疗效，安全性高，值得临床合理选用。