Objective: To compare the efficacy of methotrexate and sulfasalazine treatment of rheumatoid and non-steroidal anti-inflammatory drugs. Methods:Patients with rheumatoid arthritis disease from April 2011 to September 2013 in our hospital a total of 50 patients were randomly divided into observation mode and control groups, given the observation group were using armor ammonia Combined methotrexate sulfasalazine treatment, the control group of patients is the use of non-steroidal anti-inflammatory drugs. After 1 year of treatment, therapy and case records of adverse reactions occurred in both groups of patients. Results: After treatment, patients in the observation group total effective rate was significantly higher, the difference was statistically significant compared to (u=3.8314, P=0.0001), the indicators and the observation group were significantly better than before treatment, compared with statistically significant differences (P<0.05). Adverse reactions observed in the overall group of patients was significantly lower than the control group, the difference between the two groups was statistically significant (P<0.05). Conclusion: Compared with non-steroidal anti-inflammatory drugs, the use of methotrexate and sulfasalazine treatment of rheumatoid its more significant effect.%目的：对比甲氨蝶呤联合柳氮磺吡啶与非甾体类抗炎药治疗类风湿性关节炎的疗效。方法：选择2011年4月～2013年9月在我院就诊的类风湿性关节炎患者共50例，采用随机方式将其分为观察组和对照组，观察组给予甲氨蝶呤联合柳氮磺吡啶进行治疗，对照组则使用非甾体类抗炎药。治疗1年后，记录两组疗效以及不良反应情况。结果：观察组治疗的总有效率明显高于对照组，差异具有统计学意义（u=3.8314，P=0.0001），且观察组患者的各项指标明显优于治疗前，相比差异有统计学意义（P<0.05）。观察组不良反应总发生率明显低于对照组，差异有统计学意义（P<0.05）。结论：与非甾体类抗炎药相比，使用甲氨蝶呤联合柳氮磺吡啶治疗类风湿性关节炎的疗效更为显著。
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