正常高值血压与心血管危险因素的分析

摘要

Objective To observe the correlation between the prehypertension and cardiovascular risk factors and the risk factors of prehypertension developing into hypertension.Methods To choose 1 112 prehyertensive participants as subjects , who are accompanied by a high risk of cardiovascular disease , aged from 20 to 59 and have lived in Inner Mogonlia for at least three years.To collect such cilinical materials as age, height, weight, blood pressure and rhythm of the subjects.To collect fasting blood and measure its bio-chemical markers such as blood lipids and blood glucose , etc.Partial correlation analysis , multiple regression analysis and logistic regression analysis were applied , respectively.Results and conclusions ①Systolic blood pressure (SBP) is positively correlated with age, rhythm, triglyceride (TG) and fasting plasma glucose ( FPG);Diastolic blood pressure ( DBP) is positively correlated with age , rhythm and drinking.②The results show that major influence factors on SBP are age , rhythm, TG, family history.The major influence factors on DBP are age, gender, rhythm, BMI, drinking, family history.③With systolic and diastolic pressure of the subjects who develop into hypertention patients as virables , systolic pressure, diastolic pressure, gender, age, weight, BMI, waistline, TG, totalcholesterol (TC), HDL-C, LDL-C, FPG, hsCRP, smoking, drinking, fam-ily history as independent virable , Logistic stepwise regression analysis is performed , finding TC, hsCRP, smoking , drinking , family history are main risk factors for the development of hypertention.OR value is 1.967, 1.377, 2.197 and 1.995 respectively.BMI, hsCRP, drinking, family history, and the rising of systol-ic and diastolic pressure of the subjects are the risk factors of hypertention.OR value is 1.516, 1.814, 0.234, 2.908, 1.749, and 1.600, respectively.%目的：观察正常高值血压者与心血管危险因素之间的关系及其进展为高血压的危险因素。方法选取内蒙古自治区3年以上常住居民年龄20～59岁的正常高值血压伴心血管危险因素者共1112例，对所有研究对象收集年龄、身高、体质量、血压及心率等临床资料；采空腹血测定血脂、血糖、 hsCRP等生化指标。分别进行偏相关分析、多元逐步回归分析、 Logistic逐步回归分析。结果与结论①正常高值血压者收缩压与年龄、心率、甘油三酯、空腹血糖呈正相关；舒张压与年龄、心率、饮酒呈正相关；②年龄、心率、甘油三酯、家族史是收缩压的主要影响因素；年龄、性别、心率、 BMI、饮酒、家族史是舒张压的主要影响因素。③甘油三酯、 hsCRP 、饮酒、收缩压的增加是收缩期进展为高血压的主要危险因素， OR 值分别为1.967、1.377、2.197、1.995； BMI、hsCRP、饮酒、家族史及收缩压、舒张压的增加是舒张期进展为高血压的主要危险因素， OR值分别为1.516、1.847、0.234、2.908、1.749、1.600。