血清瘦素、BDNF水平与血管性认知功能障碍相关性研究

摘要

Objective To investigate the correlation between serum levels of leptin and brain-derived neurotrophic factor (BDNF),and cognitive function in patients with vascular cognitive impairment (VCI).Methods According to the presence of VCI,all patients with ischemic cerebrovascular disease were divided into the VCI (n =56) and control groups (n =32).Mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) were performed in two groups.The serum levels of leptin and BDNF were quantitatively measured by ELISA and statistically compared between two groups.The correlation between the MMSE,MoCA scores and serum levels of leptin and BDNF was analyzed using Pearson correlation analysis.Multi-variate correlation of vascular dementia (VaD) was performed by using Logistic regression analysis.Results In the VCI group,the serum levels of leptin and BDNF were significantly lower compared with those in the control group (both P ＜ 0.05).The serum levels of leptin and BDNF were positively correlated with the MMSE and MoCA scores in the VCI patients (r =0.371 and 0.402,both P ＜ 0.01).The ones who were elder and with lower serum levels of leptin and BDNF might have greater risk of VaD (all P ＜ 0.05).Conclusion Serum levels of leptin and BDNF are intimately correlated with the incidence of VCI,which are probably the serum markers of VCI.%目的 探讨血管性认知功能障碍(VCI)患者血清瘦素、脑源性神经营养因子(BDNF)与认知功能的相关性.方法 将缺血性脑血管患者按有无VCI分为VCI组(56例)及对照组(32例),对2组进行简易精神状态检查量表(MMSE)、蒙特利尔认知评价量表(MoCA)评估,并应用ELISA检测患者血清瘦素和BDNF水平,比较2组的检测结果.MMSE、MoCA评分结果与瘦素、BDNF的相关性采用Pearson相关分析,血管性痴呆(VaD)的多因素分析采用非条件Logistic回归分析.结果 VCI组血清瘦素和BDNF水平均低于对照组(P均＜0.05);VCI患者血清瘦素和BDNF水平与MMSE、MoCA评分呈正相关(r值为0.371、0.402,P均＜0.01).年龄越大、血清瘦素与BDNF水平越低者发生VaD的可能性越大(P均＜0.05).结论 瘦素、BDNF与VCI密切相关,可能是VCI的血清学标志物.