Objective To observe the clinical effect of lornoxicam combined with tamsulosin on acute renal colic. Methods Forty-six patients with acute renal colic were divided into two groups, with 23 patients in each group. The observation group was given intramuscular injection of 8 mg lornoxicam and oral administration of 0. 2 mg tamsulosin. The control group was given intramus-cular injection of 50 mg pethidine hydrochloride and 10 mg anisodamine. Analgesic effect,adverse events and pain recurrence were recorded in both groups. Results There were no significant differences in analgesic effect and incidence of gastrointestinal symptoms between the two groups (P -0. 35,P = 0. 208). Compared with control group, the incidences of neuropsychiatric events and other adverse reactions obviously decreased in observation group (P<0. 05). Recurrence rate of renal colic was 60. 9% (14 patients) in observation group and 91. 3% (21 patients) in control group,and the difference was significant between the two groups (P -0. 035). Conclusion The lornoxicam combined with tamsulosin was effective in the treatment of renal colic, with few ad-verse effects, low recurrence rate, safe re-use and non-addictive habit formation.%目的 观察氯诺昔康联合坦索罗辛治疗急性肾绞痛的临床疗效.方法 选择46例急性肾绞痛患者,按患者就诊时间顺序交替分成2组,每组23例.观察组给予注射用氯诺昔康8 mg肌内注射,坦索罗辛0.2 mg口服;对照组给予盐酸哌替啶50 mg、山莨菪碱(654-2)注射液10 mg肌内注射,分别观察镇痛效果、不良反应及24～48 h疼痛再发率.结果 观察组与对照组镇痛效果比较差异无统计学意义(P=0.35);消化道症状发生率2组比较差异无统计学意义(P=0.208),观察组神经精神及其他不良反应发生率明显低于对照组(均P<0.05);观察组肾绞痛再发14例(60.9%),对照组再发21例(91.3%),观察组肾绞痛再发率低于对照组(P=0.035).结论 氯诺昔康联合坦索罗辛治疗急性肾绞痛疗效确切,不良反应少,再发率低,且重复使用安全,无成瘾性.
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