非自杀性自伤与边缘性人格障碍相关性 Meta 分析

摘要

目的：系统评价非自杀性自伤（NSSI）与边缘性人格障碍（BPD）之间的相关性。方法计算机检索 Elsevi-er、PubMed、CNKI、Medline 和 WangFang Data 数据库，搜集国内外关于 NSSI 与 BPD 关系的原始研究，检索时限均为建库至2015年12月31日。在2名研究者独立进行文献筛选、资料提取和纳入研究的偏倚风险评价后，采用RevMan5．0软件进行 Meta 分析。结果共纳入9个研究。3个研究报道了 BPD 与 NSSI 的相关性，其中 NSSI 组242例，对照组1100例，Meta 分析结果显示，NSSI 组的 BPD 比例高于对照组，差异有统计学意义（Peto OR＝9．02，95％CI ：6．20～13．10）。6个研究报道了 BPD 症状评分与 NSSI 的相关性，其中 NSSI 组1751例，对照组13630例，Meta 分析结果显示，NSSI 组的 BPD 症状评分高于对照组，差异有统计学意义（SMD＝1．54，95％CI ：1．08～1．99）。结论NSSI 与 BPD 之间存在相关性。但受纳入研究的质量、数量和类型的限制，NSSI 与 BPD 是否存在因果关联有待更多证据予以验证。%Objective To systematically review the correlation between non-suicidal self-injury (NSSI)and borderline personality disorder(BPD).Methods We searched Elsevier,PubMed, CNKI,Medline and Wanfang Data from inception to December 31,2015 to collect the original studies about the relationship between NSSI and BPD.Two researchers screened literature,ex-tracted data and evaluated the risk of bias in included studies independently,and then the meta-a-nalysis was performed by using RevMan5.0.Results A total of 9 studies were included.Among them,3 studies including 242 patients and 1100 controls reported the correlation between BPD and NSSI.The meta-analysis showed that the proportion of BPD in NSSI group was higher than that in control group(Peto OR = 9.02,95%CI 6.20-13.10).Six studies including 1751 patients and 13 630 controls reported the correlation between NSSI and BPD scores.The meta-analysis showed that the BPD scores in NSSI group was higher than those in control group(SMD=1.54,95%CI 1.08-1.99).Conclusion NSSI is associated with BPD.Due to the limitation of quantity,quality and type of the included studies,the causal relationship between NSSI and BPD needs more evi-dence to be verified.