红参提取物对普罗帕酮所致大鼠急性心力衰竭的保护作用

摘要

Objective:To investigate the effects of red ginseng extracts against acute heart failure induced by Propafenone .Methods:The model of acute heart failure in rat was established with administration propafenone within femoral vein .Observed and recorded the effects of red ginseng intermediates in rats with heart failure with BL-420 E physiological recorder system .Results:The heart rate ,+dp/dtmax and -dp/dtmax were reversed by red ginseng extracts in model of acute heart failure , which was obvious difference compared with that in model animals .Conclusion:The extracts from red ginseng has a protective effects on rat acute heart failure induced by Propafenone .%目的：通过观察红参中间体对普罗帕酮所致大鼠急性心力衰竭的作用，研究红参中间体抗心力衰竭的作用。方法：股静脉注射盐酸普罗帕酮致大鼠急性心力衰竭。用BL-420 E生理记录仪系统观察记录红参中间体对心力衰竭大鼠的作用。结果：红参中间体可迅速（5 min内）恢复心力衰竭大鼠的心率，左心室内压最大上升速率和左心室内压最大下降速率与模型组相比有显著性差异。结论：红参中间体对普罗帕酮所致的大鼠急性心力衰竭有一定的保护作用。