Objective To explore and compare the treatment response of the PIs or NNRTIs - based therapeutic impact on blood corpuscle in HIV/HCV co - infected patients. Methods A randomized, open and control approach was performed to enroll the 273 cases of HIV / HCV co - infected patients on their initial visits and to choose Pis ( PIs group) or NNRTIs ( NNRTIs Group) based therapy treatment for one year. Laboratory results of hemoglobin( Hb) count, white blood cell (WBC) , red blood Cell (RBC) and platelet (PIt) were couected before and after the treatment. Results The hemoglobin count in Pis group were significantly higher than that in NNRTIs group (137.0 ±24.5g/L and 133.0 ± 14.7g/L, P<0.000), and the difference was statistically significant (P<0.01). At the end of treatment, WBC, RBC and Pit levels in NNRTIs group was significantly higher than those in Pis. In NNRTIs and Pis group respectively, WBC were (5.810 ± 1. 981) × 109/L and (4.440 ±1.244) × 109/L,Plt were (206.0 ±66.7) × 109/L and (135.0 ±42. 4) × 109/L. The difference between the two groups was statistically significant (P <0. 01). Conclusion The treatment response of NNRTIs based therapy in HIV/HCV co - infected patients can increase the degree of HCV, metabolic disease progression. There is no therapeutic impact on blood corpuscle in patients wtih HCV/HIV co - infection after Pis or NNRTIs - based regimen.%目的 探讨以蛋白酶抑制剂(PIs)或非核苷类反转录酶抑制剂(NNRTIs)为主方案治疗丙型肝炎病毒(HCV)/人类免疫缺陷病毒(HIV)合并感染的患者,比较其对血细胞的影响.方法 采用随机、开放、对照方法收集初次就诊的273例HCV/HIV合并感染患者为研究对象.分别用PIs(PIs组)或NNRTIs(NNRTIs组)为主的方案治疗.比较治疗前、后血红蛋白(Hb)、白细胞(WBC)、红血胞(RBC)、血小板(PLT)等指标.结果 治疗后PIs组和NNRTIs组Hb、WBC、PLT、RBC均有不同程度的上升,但是NNRTIs组比PIs组上升明显,Hb分别为137.0±24.5g/L和133.0±14.7g/L,WBC分别为(5.810±1.981)×109/L和(4.440±1.244)×109/L,PLT分别为(206.0±66.7)×109/L和(135.0±42.4)×109/L,两组比较差异有统计学意义(P＜0.01).结论 PIs或NNRTIs为主治疗HCV/HIV合并感染的患者对血细胞没有影响.
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