Objective To discuss plasma resistin level in obesity rats and obesity resistant rats induced by high fat diet. Methods Thirty male Wislar rats were randomly dividede into obesity inducing group 22 and normal control group 8,with high fat diet and basic diet for eight weeks. At the end of eight weeks, the high fat diets group were divided into high fat obesity group 12 and obesity resistance group 10 according to their body weight. Plasma triglyceride, total cholesterol and resistance levels of each group were determinated and obesity compared. Results Plasma triglyceride levels of high fat obesity group were significantly higher than normal control group (P<0.05) ; Total cholesterol were significantly higher than normal control group and obesity group(P <0.05, P<0.01) ; Plasma resistin level in igh fat obesity group were (lighter than normal control group and obesity resistance group (P <0.05) , and obesity resistance group weren't statistically significant difference with normal control group( P > 0.05). Conclusion Plasma resistance levels in a high - fat diet of rats induced obesity were increasing and fat rats were a certain extent of metabolism disorder which induced resistin perhaps contributed to the occuring of obesity resistance.%目的 探讨高脂饮食诱导的肥胖及肥胖抵抗大鼠血浆抵抗素水平的变化.方法 将30只Wistar雄性大鼠随机分为正常对照组8只和高脂饮食组22只,分别给予普通饮食和高脂饮食.喂养8周,观察体重变化,按体重增量,高脂饮食组大鼠又分为高脂肥胖组12只及肥胖抵抗组10只,测定并比较各组大鼠血清三酰甘油、总胆固醇及抵抗素水平.结果 高脂肥胖组大鼠血清三酰甘油水平显著高于正常对照组,有统计学意义(P＜0.05)；总胆固醇水平显著高于正常对照组和肥胖抵抗组,有统计学意义(P＜0.05,P＜0.01)；高脂肥胖组血清抵抗素高于正常对照组和肥胖抵抗组(P＜0.05),肥胖抵抗组血清抵抗素与正常对照组差异无统计学意义(P＞0.05).结论 在高脂饮食诱导的肥胖大鼠中,血浆抵抗素水平升高,并存在着血脂紊乱,而肥胖抵抗大鼠血浆抵抗素水平没有明显的变化.提示血浆抵抗素水平可能参与肥胖抵抗的发生.
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