超声造影在胃肠道恶性肿瘤肝转移新辅助化疗中临床疗效分析

摘要

Objective To probe into the value of contrast-enhanced ultreasonography in early efficacy evaluation of neoadju-vant chemotherapy in gastrointestinal malignant patients with liver metastases.Methods From April 2012 to April 2014, 47 pa-tients with gastrointestinal cancer were selected in our hospital.Based on the principle of voluntary, the patients were divided into chemotherapy group (n=22) and combination chemotherapy group (n=25).All the patients in two groups were checked with contrast-enhanced ultreasonography.The changes in quantitative parameters of each lesion before and after treatment of the valid and invalid patients in two groups were compared.Results In the chemotherapy group, 18 cases were effective, accounting for 81.82%;4 cases were ineffective, accounting for 18.18%.In combination chemotherapy group, 21 cases were effective, ac-counting for 84.00%;4 cases were ineffective, accounting for 16.00%.Compared with invalid patients in chemotherapy group, the valid patients in chemotherapy group before treatment, parameters of PI, AUS, TTP and MTT were not significant statistically ( P >0.05);at the same time, 14 d, 28 d and 42 d after treatment, the changes of parameter of PI was increased significantly, the differences were significant statistically ( P <0.05), while the parameters of AUS, TTP and MTT were not significant statisti-cally ( P >0.05).Compared with invalid patients in combination chemotherapy group, the valid patients in chemotherapy group before treatment, parameters of PI, AUS, TTP and MTT were not significant statistically ( P >0.05);at the same time, 14 d, 28 d and 42 d after treatment, the changes of parameter of PI were increased significantly, the differences were significant statisti-cally ( P <0.05), while the parameters of AUS, TTP and MTT were not significant statistically ( P >0.05).Conclusion Contrast-enhanced ultreasonography parameters of peak intensity has important significance for early efficacy evaluation of neoadju-vant chemotherapy in gastrointestinal malignant patients with liver metastases.%目的：探讨超声造影在胃肠道恶性肿瘤肝转移患者新辅助化疗中早期疗效评估中的应用价值。方法对胃肠道恶性肿瘤患者47例。依据患者自愿的原则将患者分为化疗组22例和联合化疗组25例。两组患者均采用超声造影检查。分别对两组患者中有效患者和无效患者治疗前后病灶各定量参数变化情况进行比较分析。结果化疗组患者有效18例，占81．82％；无效4例，占18．18％。联合化疗组患者有效21例，占84．00％；无效4例，占16．00％。与化疗组治疗无效患者相比，化疗组治疗前有效患者治疗前PI、AUS、TTP以及MTT等参数均无统计学意义（ P ＞0．05）；同时，治疗后第14天、28天和42天参数PI变化率明显提高，差异具有统计学意义（ P ＜0．05），而AUS、TTP以及MTT等参数变化率比较差异均不具有统计学意义（ P ＞0．05）。与联合化疗组治疗无效患者相比，化疗组治疗前有效患者治疗前PI、AUS、TTP以及MTT等参数均无统计学意义（ P ＞0．05）；治疗后第14天、28天和42天参数PI变化率明显提高，差异具有统计学意义（ P ＜0．05），而AUS、TTP以及MTT等参数变化率比较差异均不具有统计学意义（ P ＞0．05）。结论超声造影参数峰值强度在胃肠道恶性肿瘤肝转移患者新辅助化疗的早期疗效评估具有重要意义。