针刺联合阿托伐他汀对脑卒中后轻度认知障碍患者应激氧化反应及脑血流动力学的影响

摘要

Objective:To study the effect of acupuncture combined with atorvastatin on oxidative stress and cerebral hemodynamics in patients with mild cognitive impairment (MCI) after stroke.Methods:A total of 84 patients with MCI after stroke were equally divided into observation group and control group.The control group were treated with atorvastatin while the observation group were treated with acupuncture combined with atorvastatin.Changes of oxidative stress reactions and cerebral hemodynamic indexes were compared between the two groups.Results:The total effective rate of treatment for cognitive impairment was significantly higher in observation group than control group (80.95% vs 54.76%) (P<0.05).After treatment, levels of plasma 8-isoprostanes F2α (8-iso-PGF2α) and oxidized low-density lipoprotein (ox-LDL) were significantly lower in the observation group than in the control group, the mean blood flow viscosity (Vmean) and mean blood flow volume (Qmean) were significantly higher than control group (P<0.05).The peripheral resistance (R) of observation group was significantly lower than control group (P<0.05).Conclusion:Acupuncture combined with atorvastatin can significantly relieve mild cognitive impairment in stroke patients and effectively resist oxidative stress.The cerebral hemodynamic status and quality of life of patients can be improved.%目的:研究针刺联合阿托伐他汀对脑卒中后轻度认知障碍患者应激氧化反应及脑血流动力学的影响机制.方法:将某院收治的84例脑卒中后轻度认知障碍患者均分为观察组与对照组各42例,给予对照组患者阿托伐他汀治疗,给予观察组针刺联合阿托伐他汀治疗,比较两组患者应激氧化反应及脑血流动力学指标变化情况.结果:观察组患者临床认知治疗总有效率为80.95%较对照组54.76%显著较高(P<0.05);治疗后观察组患者的血浆8-异前列腺素F2α(8-iso-PGF2α)、氧化低密度脂蛋白(ox-LDL)水平较对照组显著较低(P<0.05);治疗后观察组平均血流速度(Vmean)、平均血流量(Qmean)较对照组显著较高(P<0.05);观察组外周阻力(R)水平较对照组显著较低(P<0.05).结论:针灸联合阿托伐他汀治疗可显著改善脑卒中患者轻度认知障碍,有效对抗抗氧化应激反应,患者的脑循环动力学状况得到改善,生活质量得到提高.