丝素蛋白支架的制备及其在组织工程中的应用

摘要

作为一种天然的纤维蛋白,蚕丝具有良好的力学性能、生物相容性和可降解性,这使其在生物医学方面的应用不断拓展.多孔支架能够为细胞的粘附和增殖提供有利的微环境,在重塑和修复组织的过程中起着至关重要的作用.本文综述了丝素蛋白支架的多种制备方法,如静电纺丝法、冷冻干燥法、沥除法和发泡法等,阐述了丝素蛋白支架的表面改性方法,总结了丝素蛋白支架在组织工程中的应用.%As a natural fibrous protein,silk fibroin has remarkable mechanical properties,biocompatibility and biodegradability,which makes it widely used in biomedical area.Porous scaffolds provide a favorable microenvironment for cell adhesion and proliferation and play a key role in the process of remodeling and repairing tissue.In this paper,a variety of preparation methods of silk fibroin scaffolds including electrospinning,freeze-drying,leaching and foaming.The surface modification of the silk fibroin scaffolds is described and the applications of silk fibroin scaffolds in tissue engineering are summarized.