Dynamic observation on bone mineral density of unsexed rabbits with QCT

摘要

Objective: The purpose of this tudy was to dynamicly observe the weight and the bone mineral density (BMD) of the unsexed rabbits with a few self-made standardized phantoms. Methods:The eighteen healthy adult female rabbits were measured for their weight and BMD in preunsexed and postunsexed 5 months, 10 months with quantitative CT(QCT). Results:There were 61.1% of rabbits whose weight and BMD decreased after 5 months of the postunsexed and 100% of rabbits whose weight and BMD decreased after 10 months of the operation. Conclusion:QCT can be used to dynamicly observe curative effect of drugs in various periods as well,and it is a good method to study osteoporosis.%目的:用自制标准件动态观察去势兔的体重、骨密度(BMD).方法:用定量CT(QCT)方法测量了18只健康成年雌兔去势前和去势后5个月、10个月的体重和骨密度.结果:去势后5个月有61.1%兔体重和BMD下降,而去势后10个月则100%体重和骨密度明显下降.结论:QCT可以对临床药物疗效的不同时期进行较精确的数字化动态观察,对骨质疏松的研究是较好的方法.