牛奶蛋白过敏婴幼儿常见过敏原sIgE阳性率分析

摘要

Objective:To explore the differences in the positive rates of specific-IgE(sIgE)of the common allergens between the cow's milk protein allergy(CMPA)and healthy infants and the distribution characteristics of positive sIgE of common allergens in the CMPA infants,and to provide basis for comprehensive intervention of the CMPA infants.Methods:A total of 156 cases of CMPA and 318 cases of healthy infants were selected as the subjects.The serum sIgE and total IgE levels of common allergens of the infants in two groups were detected by enzyme-linked immunosorbent assay.The differences in the positive rates of serum sIgE of common allergens and total IgE of the infants in two groups were compared.Results:There were no statistical differences in the positive rates of serum sIgE and total IgE for common allergens of the infants between CMPA group and healthy group(P>0.05).The major food allergens with high positive rates of sIgE in CMPA group were cow's milk(44.2%),egg white(10.3%)and cashew nut(5.1%),and the inhale allergens with high positive rates of sIgE were cat hair (21.2%),dog hair(9.6%)and house dust mite(4.5%).While for the healthy infants,the major food allergens with high positive rates of sIgE were cow's milk(45%),egg white(14.2%)and cashew nut(6.0%),and the inhale allergens with high positive rates of sIgE were cat hair(25.8%),dog hair(14.5%)and fungus combinations(4.5%).The analysis in different age groups(0.05).Conclusion:There are no significant differences in the serum sIgE and total IgE positive rates between the CMPA and healthy infants.The detection of serum sIgE and total IgE of common allergens is of little clinical significance for the CMPA infants.%目的:探讨牛奶蛋白过敏(CMPA)和健康婴幼儿常见过敏原特异性免疫球蛋白 E(sIgE)的阳性率差异,明确CMPA婴幼儿常见过敏原 sIgE阳性分布特征,为 CMPA患儿综合干预提供依据.方法:选择156例CMPA(CMPA组)和318名健康婴幼儿(健康组)作为研究对象,采用酶联免疫吸附法检测2组婴幼儿血清中常见过敏原 sIgE和总IgE水平,比较2组婴幼儿常见过敏原sIgE和总IgE阳性率差异.结果:CMPA组和健康组婴幼儿常见过敏原 sIgE和总 IgE的阳性率比较差异无统计学意义(P>0.05);CMPA组 sIgE阳性率较高的食物过敏原为牛奶(44.2%)、鸡蛋白(10.3%)和腰果(5.1%),sIgE阳性率较高的吸入性过敏原为猫毛皮屑(21.2%)、狗毛皮屑(9.6%)和户尘螨(4.5%);健康组 sIgE 阳性率较高的食物过敏原为牛奶(45.0%)、鸡蛋白(14.2%)和腰果(6.0%),sIgE阳性率较高的吸入性过敏原为猫毛皮屑(25.8%)、狗毛皮屑(14.5%)和真菌组合(4.5%).不同年龄段(0.05).结论:CMPA和健康婴幼儿常见过敏原血清 sIgE阳性率未发现明显差异,提示CMPA婴幼儿行血清 sIgE检测的临床指导意义证据尚显不足.