性激素结合球蛋白基因多态性与PCOS相关性研究现状

摘要

Sex hormone-binding globulin is a kind of hormone carrier protein mainly synthesized in the liver,which functions by adjusting the concentration of sex hormones. Up to now,many diseases such as Type II diabetes (T2DM),cardiovascular disease,cancer and polycystic ovary syndrome (PCOS) have been found related with serum SHBG. There is considerable heterogeneity in the results of these studies indicating the multiplicity of the factors influencing SHBG variation. However,the most important of evidences suggest that some common genetic variants of SHBG may influence SHBG levels.%性激素结合球蛋白(SHBG)是一种主要由肝脏合成的激素载体蛋白,通过调节血液中性激素的浓度发挥其生物学功能.现已发现,许多疾病如2型糖尿病(T2DM)、心血管疾病、癌症和多囊卵巢综合征(PCOS)都与血清SHBG有关.目前,对影响血清SHBG的因素的研究结果差异很大,基因多态性可能为众多因素中最重要的一种.对SHBG基因多态性的研究现状进行阐述.