中年人轻度认知功能障碍与血浆同型半胱氨酸水平的相关性研究

摘要

Objective To explore the relationship between mild cognitive impairment(MCI) and plasma homocysteine (Hcy) in middle-aged persons. Methods Plasma Hcy, plasma folic acid and VitB12 were determined respectively in 60 MCI patients (MCI group) and 60 healthy people. 32 patients with hyperhomocysteinemia (Hhcy) were treated with folic acid and VitB12 for 4 weeks. The level of Plasma Hcy, Mini-Mental State Examination (MMSE) score, and Montreal Cognitive Assessment (MCOA) score were observed before and after treatment. Results Plasma Hcy in MCI group was significantly higher than that in control group（P＜0.05）, and folic acid, VitB12 , MMSE and MCOA score were lower than that in control group（P＜0.05）. Plasma Hcy was negatively correlative with that of folic acid, VitB12, MMSE and MCOA score in MCI group（P＜0.05）. After 4 weeks’ treatments, Plasma Hcy level in MCI group reduced compared with before treatment（P＜0.05）, But MMSE and MCOA score was not statistically different compared with before treatment（P＞0.05）. Conclusion Plasma Hcy level is relevant to the occurrence of mild cognitive impairment in middle-aged persons, through adding folic acid and VitB12, level of plasma Hcy could be reduced, but no definite effect to cognitive function.%目的 探讨中年人轻度认知功能障碍(MCI)与血浆同型半胱氨酸水平的相关性.方法 测定60例MCI及60例健康体检者的血浆同型半胱氨酸(Hcy)、叶酸、维生素B12水平;MCI组高同型半胱氨酸血症32例,均给予叶酸、维生素B12治疗4周,观察Hcy水平及简易精神状态评价(MMS)E评分、蒙特利尔认知评估(MCOA)量表评分治疗前后变化.结果 MCI组Hcy水平高于对照组,差异有统计学意义(P＜0.05);叶酸、维生素B12水平及MMSE评分、MCOA量表低于对照组,差异有统计学意义(P＜0.05);MCI组中Hcy水平与叶酸、维生素B12及MMSE评分、MCOA评分均呈负相关,且差异有统计学意义(P＜0.05);MCI组高同型半胱氨酸血症(Hhcy)者治疗后4周Hcy水平较治疗前显著下降,差异有统计学意义(P＜0.05);MMSE评分、MCOA评分较治疗前差异无统计学意义(P＞0.05).结论 血浆Hcy水平与中年人轻度认知功能障碍具有相关性,补充叶酸、维生素B12可降低血浆Hcy水平,但对于改善认知功能障碍无确切疗效.