Immunology Laboratory;
Xiehe Hospital;
Tongji Medical College;
Huazhong University of Science and Technology;
Wuhan 430022;
Life Science College of Wahan University;
Wuhan 430071;
Department of Respiratory Diseases;
Tongji Hospital;
Tongji Medical College;
Huazhong University of Science and Technology;
Wuhan 430030 The relationship between 3 polymorphisms sites and adult allergic asthma in Chinawas studied. By using case-control method;
DNA and clinical data were obtained from allergic asth-matic patients and compared with those in the control subjects. The subjects were genotyped for theIL-4 C-589T promoter polymorphism;
the IL-4R αchain Q576R and the AICDA C8408T by poly-merase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The resultsshowed that the IL-4 C-589T was not associated with adult allergic asthma in China. However;
theIL-4R αchain 576R/R and AICDA 8408T/T frequency was significantly increased in allergic asthmagroup as compared with that in the control group P<0.01)] and was correlated with the increased plasma total IgE. These data suggested that theIL-4R αchain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergicasthma in China.;