金黄益胆颗粒对原发性胆管结石病人术后血浆胃肠激素水平的影响

摘要

To evaluate the clinical therapeutic mechanism of Jinhuangyidankeli. Methods Motilin(MoT) Soma tostatin( SS)and SP in the blood of the outside vein from the Primary Bile Duct Stones limosis Patients were measured with radioimmu-noassay. The levels of stomach-intestines hormone from the control group, recovering group and Jinhuangyidankeli group were compared. Results MTL and SP concentration in the blood of the outside vein from the primary bile duct stones patients decreased, but SS increased in than the healthy human; somatostatin(SS)and SP concentration in the blood of the outside vein is awfully different in recovering group and Jinhuangyidankeli group. The somatostatin concentration in Jinhuangyidankeli group is considered arrived at the level of the control group and SP is close to the control group. Conclusion Jinhuangyidankeli could increase the SP concentration and decrease the SS concentration in the Primary Bile Duct Stones Patients,which might be related to prevention of Pigment Stones.%目的 探讨金黄益胆颗粒临床作用机理.方法 采用放射免疫分析法(RIA)测定原发性胆管结石病人空腹外周静脉血浆胃动素(MOT)、生长抑素(SS)、SP的含量.比较服药组(金黄益胆颗粒组)、对照组(自然恢复组)、正常组(正常健康人)体内血浆胃肠激素水平.结果 正常组空腹血浆胃动素水平、P物质水平比胆管结石病人高,生长抑素水平比胆管结石病人低；服药组生长抑素达到正常组水平、SP接近正常组水平,均与对照组差异明显.结论 金黄益胆颗粒具有调节SS、SP的作用,预防胆色素结石的机理与此有关.