Objective: to observe the clinical effectiveness of Liangxue Jiedu Gao( ointment for cooling blood to remove toxic materials ) in treating acute radioactive cutaneous injury. Methods: 100 cases awaiting radiation therapy were randomly divided into two groups, 50 cases each group. Chinese medicine group was applied with the ointment onto the local area during the first radiation treatment; control group was given routine publicizing and health education for radiation treatment. Results: The total incidence rate of radioactive cutaneous injury was 100% in control group, and 84% in Chinese medicine group ( P <0. 05 ); I radiation reaction was 38% in control group ( 19/50 ), and 60% in Chinese medicine group ( 30/50 ); II was 30% ( 15/50 ) and 22% ( 11/50 ); III was 20% ( 10/50 ) and 2% ( 1/50 ), IV was 12% ( 6/50 ) and 0% ( 0/50 ). Exposure dose of cutaneous injury for the first time was 26. 3 Gy and 38. 9 Gy ( P <0. 01 ). Before 40 Gy, 96% ( 48 cases ) of control group had cutaneous injury while 64% ( 32/50 ) of Chinese medicine group did. Conclusion: Liangxue Jiedu Gao can prevent the incidence of cutaneous injury, prolong the incidence time and lower the injury degree.%目的:观察凉血解毒膏防治急性放射性皮肤损伤的临床疗效.方法:将100例需要放射治疗的患者随机分为2组,每组50人.中药组在第一次放射治疗时给予凉血解毒膏涂抹局部;对照组只做常规放射治疗宣教和健康教育.结果:放射性皮肤损伤的总发生率对照组为100%,中药组为84%(P<0.05),I级放射反应对照组为38%(19/50),中药组为60%(30/50),II级放射反应对照组为30%(15/50),中药组为22%(11/50),III级放射反应对照组为20%(10/50),中药组为2%(1/50),IV级放射反应对照组为12%(6/50),中药组为0%(0/50).第一次出现皮肤损伤的照射剂量对照组为26.3 Gy,中药组为38.9Gy(P<0.01).在40 Gy以前,对照组有96%(48/50)的患者发生皮肤反应,中药组仅为64%(32/50).结论:凉血解毒膏能有效地防治放射性皮炎的发生,并能延长发生时间,降低皮肤损伤程度.
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