Objective To observe the influences of hypertonic sodium chloride hydroxyethyl starch 40 injection on hemodynamics during induction of general anesthesia for shock patients. Methods Forty cases of shock patients were selected and randomly divided into control group and experimental group with 20 cases each. Control group were infused with compound sodium chloride and experimental group were infused with hypertonic sodium chloride hydroxyethyl starch 40 injection. Results The changing tendency of the hemodynamics of two groups were same. The systolic blood pressure, diastolic blood pressure and central venous pressure among 5,10,15min after induction were all significantly higher than preinduction period, and the heart rate significantly lower than preinduction period ( P ＜ 0. 01 ). Meanwhile the systolic blood pressure, diastolic blood pressure and central venous pressure at 10, 15min after induction in experimental group were all significantly higher than control group ( P ＜0. 01 ), and the heart rate in experimental group were all significantly lower than control group ( P ＜ 0. 01 ). Conclusion Hypertonic sodium chloride hydroxyethyl starch 40 injection can maintain hemodynamic stability of shock patients during the anesthesia induction period, prevente the descent of blood pressure, maintain the stable of heart rate, increase the regulative ability of the cardiovascular system, but the infuse volume of hypertonic sodium chloride hydroxyethyl starch 40 injection should be controlled and also the central venous pressure and electrolytes should be monitored.%目的 观察高渗氯化钠羟乙基淀粉40注射液快速扩容对休克患者全麻诱导期血流动力学的影响.方法 选择急诊失血性休克患者40例,随机分为试验组和对照组,对照组为复方氯化钠组,试验组为高渗氯化钠羟乙基淀粉40组,每组20例,对照组快速输注复方氯化钠,试验组输注高渗氯化钠羟乙基淀粉40,输液速度为15mL·kg-1·h-1.结果 2组患者全麻诱导期血流动力学的变化趋势一致,2组诱导后5、10、15min时段收缩压、舒张压及中心静脉压均较基础值明显上升(P<0.01),心率明显减慢(P<0.01);其中试验组在诱导后10、15min时段的收缩压、舒张压及中心静脉压均较对照组明显升高(P<0.01),而心率较对照组明显减慢(P<0.01).结论 高渗氯化钠羟乙基淀粉40注射液可维持休克患者全麻诱导期血流动力学稳定,防止麻醉诱导期血压下降,保持心率平稳,增强心血管系统的调节能力,但应控制输入总量,并应监测中心静脉压与电解质.
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