W/O型木犀草素微乳液的制备

摘要

To develop the W/O microemulsion of luteolin. The soybean oil as oil phase, selected the appropriate surfactant and cosurfactant, used the pseudo-ternary phase diagram to study the microemulsion formulations. The solubility of luteolin was determined in the oil phase and microemulsion. And the initial stability of luteolin microemulsion was investigated. The optimal composition of Span80: Tween80: ethanol: oil: water in microemulsion was followed as 4. 2:1.4: 1.4: 3: 1. The solubility of luteolin in the oil and microemulsion were determined 18. 12 (μg/mL,755.03 μg/mL. Luteolin microemulsion could increase its solubility in the oil.%制备W/O型木犀草素微乳.以大豆油为油相,选择适当的表面活性剂和助表面活性剂,利用伪三元相图筛选微乳配方,测定了木犀草素在油相和微乳中的溶解度,并考察了木犀草素微乳的初步稳定性.微乳的最佳质量配比为司班∶吐温∶乙醇∶油∶水为4.2∶1.4∶1.4∶3∶1.测定的木犀草素在大豆油、微乳中的溶解度分别为18.12、755.03 μg/mL.木犀草素微乳提高了其在油中的溶解度.