COPD合并肺部感染患者接受盐酸氨溴索支气管肺泡灌洗后全身炎症及应激反应的评估

摘要

目的:探讨COPD合并肺部感染患者接受盐酸氨溴索支气管肺泡灌洗后全身炎症及应激反应的评估.方法:收集2015年10月～2017年1月至本院就医的COPD合并急性肺部感染患者78例作为研究对象,经随机数表法分为对照组、研究组各39例.对照组接受常规治疗,研究组接受常规+盐酸氨溴索支气管肺泡灌洗治疗.对比两组治疗前及治疗1周后血清中炎症因子、氧化应激指标含量的差异.结果:治疗前,两组血清中炎症因子、氧化应激指标含量的差异无统计学意义.治疗1周后,研究组血清中炎症因子IL-2、IL-6、IL-8、TNF-α、CRP、PCT的含量低于对照组;血清中氧化指标MDA、MPO、AOPPs的含量低于对照组,抗氧化指标SOD、T-AOC、GSH-Px的含量高于对照组.结论:COPD合并肺部感染患者接受盐酸氨溴索支气管肺泡灌洗治疗,可显著抑制全身炎症及氧化应激反应,有助于病情控制.%Objective:To evaluate the systemic inflammatory and stress response in patients with COPD complicated by pulmonary infection after bronchoalveolar lavage with ambroxol hydrochloride.Methods:78 patients with COPD complicated by acute pulmonary infection who were treated in the hospital between October 2015 and January 2017 were collected as research subjects and divided into control group (n =39) and study group (n =39) by random number table.Control group received routine treatment,and study group received the routine + bronchoalveolar lavage with ambroxol hydrochloride.The differences in serum levels of inflammatory factors and oxidative stress indexes were compared between the two groups before treatment and after 1 week of treatment.Results:There was no statistically significant difference in serum levels of inflammatory factors and oxidative stress indexes between the two groups before treatment.After 1 week of treatment,serum inflammatory factors IL-2,IL-6,IL-8,TNF-α,CRP and PCT levels of study group were lower than those of control group;serum oxidation indexes MDA,MPO and AOPPs levels were lower than those of control group while anti-oxidation indexes SOD,TAOC and GSH-Px levels were higher than those of control group.Conclusion:Bronchoalveolar lavage with ambroxol hydrochloride can significantly inhibit the systemic inflammatory and oxidative stress response and help control the disease in patients with COPD complicated by pulmonary infection.