支原体肺炎患儿血清补体、免疫球蛋白含量与炎症应激反应的相关性分析

摘要

目的:研究支原体肺炎患儿血清补体C3 、C4及免疫球蛋白IgM 、IgA 、IgG含量与炎症应激反应的相关性.方法:选择湖北医药学院附属襄阳市第一人民医院2015年2月～2018年1月期间诊断为支原体肺炎的患儿作为M PP组、另取同期健康体检的儿童作为对照组.测定血清中补体、免疫球蛋白、炎症应激介质的含量以及外周血中炎症应激分子的表达量.结果:M PP组患儿血清中C3 、C4 、IgM 、sICAM-1 、CD40L 、HMGB1 、Cor 、MDA的含量以及外周血中 TLR2 、TLR4 、CD11b 、CD18 、MPO 、NOX2的表达强度显著高于对照组,IgA 的含量显著低于对照组,IgG 的含量与对照组比较无差异;MPP组患儿血清中C3 、C4 、IgM 的含量与血清中sICAM-1 、CD40L 、HMGB1 、Cor 、MDA的含量以及外周血中TLR2 、TLR4 、CD11b 、CD18 、MPO 、NOX2的表达强度呈正相关,血清中IgA 的含量与血清中sICAM-1 、CD40L 、HMGB1 、Cor 、MDA的含量以及外周血中TLR2 、TLR4 、CD11b 、CD18 、MPO 、NOX2的表达强度呈负相关.结论:支原体肺炎患儿血清补体、免疫球蛋白的变化与病程中炎症应激反应的过度激活有关.%Objective :To study the correlation of serum complements C3 and C4 as well as immunoglobulins IgM ,IgA and IgG contents with inflammatory stress response in children with mycoplasma pneumoniae pneumonia .Methods :The chil-dren who were diagnosed with mycoplasma pneumoniae pneumonia in Xiangyang No .1 Peopleˊs Hospital ,Hubei University of Medicine between February 2015 and January 2018 were selected as the MPP group ,and healthy children who received physical examination during the same period were selected as the control group .The contents of complements ,immunoglobulins and in-flammatory stress mediators in serum as well as the expression of inflammatory stress molecules in peripheral blood were measured .Results :Serum C3 ,C4 ,IgM ,sICAM-1 ,CD40L ,HMGB1 ,Cor and MDA levels as well as peripheral blood TLR2 , TLR4 ,CD11b ,CD18 ,MPO and NOX2 expression intensity of MPP group were significantly higher than those of control group ,IgA level was significantly lower than that of control group ,and IgG level was not different from that of control group ;serum C3 ,C4 and IgM levels of MPP group were positively correlated with serum sICAM-1 ,CD40L ,HMGB1 ,Cor and MDA levels as well as peripheral blood TLR2 ,TLR4 ,CD11b ,CD18 ,MPO and NOX2 expression intensity ,and serum IgA level was negatively correlated with serum sICAM-1 ,CD40L ,HMGB1 ,Cor and MDA levels as well as peripheral blood TLR2 , TLR4 ,CD11b ,CD18 ,MPO and NOX2 expression intensity .Conclusion :The changes of serum complements and immuno-globulins in children with mycoplasma pneumoniae pneumonia are related to the excessive activation of inflammatory stress re-sponse in the course of disease .