目的:研究细菌性血流感染早期血培养阳性和阴性患者血清炎症反应介质的差异.方法:选择因疑似细菌性血流感染入院的患者并根据血培养结果分为阳性组和阴性组,另取同期体检的健康志愿者作为对照组.入院时取疑似菌血症患者的外周血标本,体检时取对照组志愿者的外周血标本,测定促炎细胞因子、抑炎细胞因子、黏附及趋化因子的含量.结果:阳性组、阴性组患者血清中PCT、CRP、IL-6、IL-17、IL-23、IL-4、IL-10、IL-13、sTM、ICAM-1、VCAM-1、EOTAXIN-3、MCP-1的含量均显著高于对照组,阳性组患者血清中PCT、CRP、IL-6、IL-17、IL-23、IL-4、IL-10、IL-13、sTM、ICAM-1、VCAM-1、EOTAXIN-3、MCP-1的含量均显著高于阴性组.结论:血清炎症反应介质的检测能够早期预测细菌性血流感染.%Objective:To study the differences in serum inflammatory mediators in early blood culture positive and neg-ative patients with bacterial bloodstream infection .Methods:Patients who were hospitalized due to suspected bacterial blood-stream infection between December 2015 and September 2017 were divided into positive group and negative group according to the results of blood culture ,and healthy volunteers who underwent medical examination during the same period were selected as control group .Peripheral blood specimens were collected from patients with suspected bacteremia on admission ,the periph-eral blood specimens were collected from the control group of volunteers during physical examination ,and the levels of pro-in-flammatory cytokines ,anti-inflammatory cytokines ,adhesion factors and chemokines were determined .Results:Serum PCT , CRP ,IL-6 ,IL-17 ,IL-23 ,IL-4 ,IL-10 ,IL-13 ,sTM ,ICAM-1 ,VCAM-1 ,EOTAXIN-3 and MCP-1 levels of positive group and negative group were significantly higher than those of control group ,and serum PCT ,CRP ,IL-6 ,IL-17 ,IL-23 ,IL-4 ,IL-10 ,IL-13 ,sTM ,ICAM-1 ,VCAM-1 ,EOTAXIN-3 and MCP-1 levels of positive group were significantly higher than those of negative group .Conclusion:Detection of serum inflammatory mediators can early predict the bacterial bloodstream infection .
展开▼
