Objective:To investigate the effect and safety of nano-carbon on shoulder joint after lymphatic chemotherapy for breast cancer. Methods:164 patients Breast cancer patients, Sc group (docetaxel + CNP), Dd group (docetaxel), Sc group and Dd group were selected to observe shoulder joint function, docetaxel concentration in Sc group and Dd group after 12 h, 24 h, 36 h and 48 h injection of chemotherapy, apoptotic index of metastatic lymph nodes, apoptosis rate of lymph node cells, Sc group and Dd group were observed. The occurrence of adverse reactions. Results:The concentration of paclitaxel in the lymph nodes of the Sc group was significantly higher than that of the Dd group at 12h, 24h, 36, 48h. The concentration of paclitaxel was the highest in the group of 24h in the Sc group, and the lowest in the 48h group. 0.05);The AI index of the chemotherapy group was significantly higher than that of the Dd group at 12h, 24h, 36, 48h in the Sc group (P0.05). The apoptosis rate of lymphocytes in the group of 12h, 24h, 36th and 48h in the Sc group was significantly higher than that in the Dd group (P0.05);the incidence of adverse reactions in the Dd group (15%) was higher than that in the Sc group (7.1%), but there was no difference (P>0.05);There was no significant difference in the function of shoulder joint function between the Dd group and the Dd group (P>0.05). The score of the shoulder joint function score in the Sc group was increased compared with the Dd group (P<0.05). Conclusions:Carbon nanoparticles are of high value and safety in the application of lymphatic chemotherapy to shoulder joint after breast cancer surgery, which is worthy of wide application in clinical treatment of breast cancer.
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