Engineered exosomes targeting technology and potential in the field of peripheral nerve injury repair

摘要

Exosomes have good stability,biocompatibility,bio-barrier permeability,as well as low immunogenicity and low toxicity,and have great potential for therapeutic and targeted drug delivery applications.Inserting a targeting ligand into the surface of the exosomes through genetic engineering will enable targeted targeting of diseased tissues or organs and therapeutic effects.This article reviews the production and function of exosomes,the current methods of drug loading into exosomes,and targeting techniques.In addition,the potential of engineered exosomes in the field of peripheral nerve injury repair is also discussed,providing a new solution for targeted therapy of peripheral nerve injury.