Effects of etomidate maintenance anesthesia on immunoglobulin and stress response levels in patients with gastric cancer after operation

摘要

Objective: To investigate the effect of etomidate maintenance anesthesia on immune function and stress response in patients with gastric cancer after the operation. Methods: 160 patients with gastric cancer in our hospital were randomly divided into control group and observation group, with 80 cases in each group. Both of the groups underwent radical gastrectomy, in which the control group was injected propofol anesthesia, while the observation group was injected etomidate anesthesia. The levels of immunoglobulin A, immunoglobulin M, immunoglobulin G, cortisol(Cor), aldosterone(ALD), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) were detected and compared before and after treatment. Results: After treatment, the serum levels of immunoglobulin A, immunoglobulin G and immunoglobulin M of the patients in the control group were significantly decreased. But in the observation group, these serum level did not change significantly and were higher compared with the control group. The serum levels of Cor, ALD, SOD, and GSH-Px in both groups after treatment were significantly decreased, while the levels of MDA, TNF-α and hs-CRP were significantly increased. The serum levels of Cor, ALD, MDA, TNF-α, and hs-CRP of patients in the observation group were significantly lower than those in the control group, and the levels of SOD and GSH-Px were significantly higher than those in the control group. Conclusion: Etomidate can enhance the immune function and antioxidant capacity of patients with gastric cancer, alleviate inflammation, and has a good clinical effect. But it is not suitable for patients with severe impairment of adrenocortical function.