Changes of renal function impairment, extracellular matrix regulation, renal fibrosis and inflammation in patients with chronic glomerulonephritis

摘要

Objective: To investigate the changes and clinical significance of renal function impairment, extracellular matrix regulation, renal fibrosis and inflammation in patients with chronic glomerulonephritis. Methods: A total of 50 patients with chronic glomerulonephritis admitted to our hospital from May 2016 to February 2018 were selected as observation group and 50 healthy people as control group.The expression levels and related inflammatory markers of renal dysfunction [including Uric acid (UA), retinol binding protein (RBP) and type IV collagen (Col-IV)], extracellular matrix modulation [including tissue inhibitor of metalloproteinase -1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9)], renal fibrosis [including transforming growth factor β1 (TGF-β1), laminin (LN) and hyaluronic acid (HA).] and degree of inflammation [including leukocyte stimulating hormone-1 (Lkn-1) and tumor necrosis factor-α (TNF-α)] were observed and compared between the two groups. Results:The changes of renal function impairment, extracellular matrix regulation, renal fibrosis and inflammation were significant in both groups. Compared with healthy controls in the control group, UA[(352.49±26.57) μmol/L], RBP[(98.75±26.91) mg/L], Col-IV[(224.77±72.32) ng/L], TIMP-1[(145.79±49.67) ng/mL], MMP-9[(177.71±52.35) ng/mL], TGF-β1[(15.23±7.61) ng/mL], LN[(153.82±23.01) μg/L], HA[(366.80±77.98) μg/L], Lkn-1[(82.71±20.64) pmol/L] and TNF-α[(138.01±45.26) pg/mL] levels were significantly elevated. The differences were statistically significant. Conclusions: Chronic glomerulonephritis patients with renal dysfunction and abnormal regulation of extracellular matrix, and severe renal fibrosis, the body is at a higher level of inflammation, clinical indicators should be strengthened to detect the early diagnosis of the disease and treatment basis.